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1

Antibody Conjugation of a Chimeric BET Degrader Enables In Vivo Activity

Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy

Journal:

Year:

2019

Language:

english

File:

PDF, 1.68 MB

english, 2019

2

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Amrita V. Kamath, Jian Wang, Francis Y. Lee, Punit H. Marathe

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 341 KB

english, 2008

3

Effect of fruit juices on the oral bioavailability of fexofenadine in rats

Amrita V. Kamath, Ming Yao, Yueping Zhang, Saeho Chong

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 94 KB

english, 2005

4

Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies

Kamath, Amrita V.

Journal:

Drug Discovery Today: Technologies

Year:

2016

Language:

english

File:

PDF, 377 KB

english, 2016

5

Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose

Amrita V. Kamath, Dan Lu, Priyanka Gupta, Denise Jin, Hong Xiang, Anne Wong, Cecilia Leddy, Lisa Crocker, Gabriele Schaefer, Mark X. Sliwkowski, Lisa A. Damico-Beyer

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 350 KB

english, 2012

6

Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables inâvivo Activity (ChemMedChem 1/2020)

Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy

Journal:

Year:

2020

File:

PDF, 443 KB

2020

7

Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors

Zhen-wei Cai, Donna Wei, Robert M. Borzilleri, Ligang Qian, Amrita Kamath, Steven Mortillo, Barri Wautlet, Benjamin J. Henley, Robert Jeyaseelan Sr., John Tokarski, John T. Hunt, Rajeev S. Bhide, Jose

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

8

Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma

Amrita V. Kamath, Dan Lu, Priyanka Gupta, Denise Jin, Yan Xin, Ann Brady, Jean-Philippe Stephan, Hao Li, Janet Tien, Jing Qing, Lisa A. Damico-Beyer

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 426 KB

english, 2012

9

Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus , in a mouse model

Wang-Lin, Shun xin, Zhou, Chenguang, Kamath, Amrita V., Hong, Kyu, Koppada, Neelima, Saad, Ola M., Carrasco-Triguero, Montserrat, Khojasteh, Cyrus, Deng, Rong

Journal:

Year:

2018

Language:

english

File:

PDF, 2.69 MB

english, 2018

10

Discovery and Evaluation of N -Cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a Selective and Orally Efficacious Inhibitor of Vascular Endothelial Growth Factor Receptor-2

Borzilleri, Robert M., Bhide, Rajeev S., Barrish, Joel C., D'Arienzo, Celia J., Derbin, George M., Fargnoli, Joseph, Hunt, John T., Jeyaseelan, Robert, Kamath, Amrita, Kukral, Daniel W., Marathe, Puni

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

11

Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1- f ][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors

Borzilleri, Robert M., Zheng, Xiaoping, Qian, Ligang, Ellis, Christopher, Cai, Zhen-wei, Wautlet, Barri S., Mortillo, Steve, Jeyaseelan,, Robert, Kukral, Daniel W., Fura, Aberra, Kamath, Amrita, Vyas,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

12

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats

Amrita V. Kamath, Saeho Chong, Ming Chang, Punit H. Marathe

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 262 KB

english, 2005

13

Potent and Sustained Activity of Novel THIOMAB™ Antibiotic Conjugate (TAC) Against Staphylococcus aureus as Measured by Bioluminescence Imaging

Zhou, Chenguang, Baruch, Amos, Ramanujan, Saroja, Pillow, Thomas, Yang, Meng, Guo, Fengxun, Xu, Deming, Kamath, Amrita

Journal:

Open Forum Infectious Diseases

Year:

2016

Language:

english

File:

PDF, 158 KB

english, 2016

14

A phase 1, randomized, single ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of DSTA4637S, an anti- Staphylococcus aureus THIOMAB™ antibody-antibiotic conjugate, in healthy volunteers

Peck, Melicent, Rothenberg, Michael E., Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V., Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S., Le

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2019

Language:

english

File:

PDF, 624 KB

english, 2019

15

Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics

Famili, Amin, Crowell, Susan, Loyet, Kelly M., Mandikian, Danielle, Boswell, C Andrew, Cain, David, Chan, Joyce, Comps-Agrar, Laetitia, Kamath, Amrita, Rajagopal, Karthikan

Journal:

Bioconjugate Chemistry

Year:

2019

Language:

english

File:

PDF, 558 KB

english, 2019

16

Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics

Famili, Amin, Crowell, Susan, Loyet, Kelly M., Mandikian, Danielle, Boswell, C Andrew, Cain, David, Chan, Joyce, Comps-Agrar, Laetitia, Kamath, Amrita, Rajagopal, Karthikan

Journal:

Bioconjugate Chemistry

Year:

2019

File:

PDF, 558 KB

2019

17

Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1

Yan, Boxu, Boyd, Daniel, Kaschak, Timothy, Tsukuda, Joni, Shen, Amy, Lin, Yuwen, Chung, Shan, Gupta, Priyanka, Kamath, Amrita, Wong, Anne, Vernes, Jean-Michel, Meng, Gloria Y., Totpal, Klara, Schaefer

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

18

Characterization of Tissue Distribution, Catabolism and Elimination of an Anti- Staphylococcus aureus THIOMAB TM Antibody-Antibiotic Conjugate in Rats

Cai, Hao, Yip, Victor, Lee, M. Violet, Wong, Sylvia, Saad, Ola, Ma, Shuguang, Ljumanovic, Nina, Khojasteh, S. Cyrus, Kamath, Amrita V., Shen, Ben-Quan

Journal:

Drug Metabolism and Disposition

Year:

2020

File:

PDF, 10.70 MB

2020

19

Antibody-drug Conjugates Derived From Cytotoxic seco-CBI-Dimer Payloads are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo

Su, Dian, Chen, Jinhua, Cosino, Ely, Cruz-Chuh, Josefa dela, Davis, Helen, Del Rosario, Geoffrey, Figueroa, Isabel, Goon, Leanne, He, Jintang, Kamath, Amrita, Kaur, Surinder, kozak, katherine, Lau, Je

Journal:

Bioconjugate Chemistry

Year:

2019

File:

PDF, 1.40 MB

2019

20

Choline Uptake in Human Intestinal Caco-2 Cells Is Carrier-Mediated

Kamath, Amrita V., Darling, Inger M., Morris, Marilyn E.

Journal:

Journal of Nutrition

Year:

2003

Language:

english

File:

PDF, 123 KB

english, 2003

21

Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog

Amrita V. Kamath, Ming Chang, Francis Y. Lee, Yueping Zhang, Punit H. Marathe

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 314 KB

english, 2005

22

Preclinical pharmacokinetics and in vitro metabolism of brivanib (BMS-540215), a potent VEGFR2 inhibitor and its alanine ester prodrug brivanib alaninate

Punit H. Marathe, Amrita V. Kamath, Yueping Zhang, Celia D’Arienzo, Rajeev Bhide, Joseph Fargnoli

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 373 KB

english, 2009

23

Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats

Sharma, Ajitha, Shetty, Manjunath, Parida, Amrita, Adiga, Shalini, Kamath, Shobha, , Sowjanya

Journal:

Pharmacognosy Research

Year:

2014

Language:

english

File:

PDF, 583 KB

english, 2014

24

Challenges and advances in the assessment of the disposition of antibody-drug conjugates

Kamath, Amrita V., Iyer, Suhasini

Journal:

Biopharmaceutics & Drug Disposition

Year:

2016

Language:

english

File:

PDF, 377 KB

english, 2016

25

Functional expression of P-glycoprotein in the hepatic canalicular membrane of developing rats

Amrita V. Kamath, Marilyn E. Morris

Journal:

Journal of Pharmaceutical Sciences

Year:

1998

Language:

english

File:

PDF, 72 KB

english, 1998

26

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

Kamath, Amrita V., Iyer, Suhasini

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 1004 KB

english, 2015

27

Preclinical discovery of ixabepilone, a highly active antineoplastic agent

Francis Y. F. Lee, Robert Borzilleri, Craig R. Fairchild, Amrita Kamath, Richard Smykla, Robert Kramer, Gregory Vite

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 451 KB

english, 2008

28

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor

Réjean Ruel, Carl Thibeault, Alexandre L’Heureux, Alain Martel, Zhen-Wei Cai, Donna Wei, Ligang Qian, Joel C. Barrish, Arvind Mathur, Celia D’Arienzo, John T. Hunt, Amrita Kamath, Punit Marathe, Yuepi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 146 KB

english, 2008

29

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A,

Journal:

Year:

2014

Language:

english

File:

PDF, 889 KB

english, 2014

30

Complex formation of antiâVEGFâC with VEGFâC released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Bumbaca Yadav, Daniela, Reyes, Arthur E., Gupta, Priyanka, Vernes, JeanâMichel, Meng, Y. Gloria, Schweiger, Michelle G., Stainton, Shannon L., Fuh, Germaine, Fielder, Paul J., Kamath, Amrita V., She

Journal:

Pharmacology Research & Perspectives

Year:

2020

File:

PDF, 1.55 MB

2020

31

Effect of Organic Isothiocyanates on the P-Glycoprotein- and MRP1-Mediated Transport of Daunomycin and Vinblastine

Elaine Tseng, Amrita Kamath, Marilyn E. Morris

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 187 KB

english, 2002

32

Inhibitors of P-glycoprotein-mediated daunomycin transport in rat liver canalicular membrane vesicles

Younggil Kwon, Amrita V. Kamath, Marilyn E. Morris

Journal:

Journal of Pharmaceutical Sciences

Year:

1996

Language:

english

File:

PDF, 114 KB

english, 1996

33

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

Deng, Rong, Zhou, Chenguang, Li, Dongwei, Cai, Hao, Sukumaran, Siddharth, Carrasco-Triguero, Montserrat, Saad, Ola, Nazzal, Denise, Lowe, Christopher, Ramanujan, Saroja, Kamath, Amrita V.

Journal:

Year:

2019

File:

PDF, 4.82 MB

2019

34

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

Zhou, Chenguang, Cai, Hao, Baruch, Amos, Lewin-Koh, Nicholas, Yang, Meng, Guo, Fengxun, Xu, Deming, Deng, Rong, Hazenbos, Wouter, Kamath, Amrita V., Hamblin, Michael R.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.48 MB

english, 2019

35

Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: Role of paracellular transport, binding to trypsin, and P-glycoprotein efflux

Amrita V. Kamath, Richard A. Morrison, Timothy W. Harper, Shih-Jung Lan, Anthony M. Marino, Saeho Chong

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 111 KB

english, 2005

36

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

Gupta, Priyanka, Kamath, Amrita, Park, Summer, Chiu, Henry, Lutman, Jeff, Maia, Mauricio, Tan, Man-Wah, Xu, Min, Swem, Lee, Deng, Rong

Journal:

Year:

2016

Language:

english

File:

PDF, 1.37 MB

english, 2016

37

Balancing the Affinity and Pharmacokinetics of Antibodies by Modulating the Size of Charge Patches on Complementarity-Determining Regions

Sun, Yue, Cai, Hao, Hu, Zhilan, Boswell, C. Andrew, Diao, Jinpian, Li, Charlene, Zhang, Liangyi, Shen, Amy, Teske, Christopher A., Zhang, Boyan, Kamath, Amrita V., Jiang, Guoying

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 1.10 MB

2020

38

Modulation of tight junctions does not predict oral absorption of hydrophilic compounds: Use of caco-2 and calu-3 cells

Amrita V. Kamath, Richard A. Morrison, Neil R. Mathias, Sandra A. Dando, Anthony M. Marino, Saeho Chong

Journal:

Archives of Pharmacal Research

Year:

2007

Language:

english

File:

PDF, 495 KB

english, 2007

39

Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic

Stagg, Nicola J., Shen, Ben-Quan, Brunstein, Flavia, Li, Chunze, Kamath, Amrita V., Zhong, Fiona, Schutten, Melissa, Fine, Bernard M.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.54 MB

english, 2016

40

Assessment of mutagenicity caused by popular baby foods and baby plastic-ware products: An imperative study using microbial bioassays and migration analysis

Nepalia, Amrita, Singh, Anuradha, Mathur, Nupur, Kamath, Rajashree, Pareek, Smita

Journal:

Ecotoxicology and Environmental Safety

Year:

2018

Language:

english

File:

PDF, 1.52 MB

english, 2018

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